3D7G

A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCMC, a urea-based inhibitor

3D7G の概要

• エントリーDOI: 10.2210/pdb3d7g/pdb
• 関連するPDBエントリー: 3D7D 3D7F 3D7H
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: prostate specific membrane antigen (psma); metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase, dcmc, urea-based inhibitor, carboxypeptidase, dipeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83221.34

構造登録者

Lubkowski, J.,Barinka, C. (登録日: 2008-05-21, 公開日: 2008-12-30, 最終更新日: 2023-08-30)

• 主引用文献: Barinka, C.,Byun, Y.,Dusich, C.L.,Banerjee, S.R.,Chen, Y.,Castanares, M.,Kozikowski, A.P.,Mease, R.C.,Pomper, M.G.,Lubkowski, J.; Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization; J.Med.Chem., 51:7737-7743, 2008; PubMed: 19053759; DOI: 10.1021/jm800765e

実験手法

X-RAY DIFFRACTION (1.75 Å)