3D6N

Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase

Summary for 3D6N

• Entry DOI: 10.2210/pdb3d6n/pdb
• Related: 1xrf 1xrt
• Descriptor: Dihydroorotase, Aspartate carbamoyltransferase, ZINC ION, ... (5 entities in total)
• Functional Keywords: reactor, chamber, pores, internal cavity, hydrolase, metal-binding, pyrimidine biosynthesis, transferase, hydrolase-transferase complex, hydrolase/transferase
• Biological source: Aquifex aeolicus; More
• Total number of polymer chains: 2
• Total formula weight: 80490.88

Authors

Edwards, B.F.P. (deposition date: 2008-05-20, release date: 2009-01-20, Last modification date: 2023-08-30)

• Primary citation: Zhang, P.,Martin, P.D.,Purcarea, C.,Vaishnav, A.,Brunzelle, J.S.,Fernando, R.,Guy-Evans, H.I.,Evans, D.R.,Edwards, B.F.; Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.; Biochemistry, 48:766-778, 2009; PubMed: 19128030; DOI: 10.1021/bi801831r

Experimental method

X-RAY DIFFRACTION (2.3 Å)