3D6H

Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)

Summary for 3D6H

• Entry DOI: 10.2210/pdb3d6h/pdb
• Related: 1sc3 3d6f 3d6m
• Related PRD ID: PRD_000338
• Descriptor: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide, ... (4 entities in total)
• Functional Keywords: catalytic domain, naturally-occurring mutation, apoptosis, hydrolase, protease, thiol protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P29466 P29466
• Total number of polymer chains: 3
• Total formula weight: 30835.87

Authors

Rosen-Wolff, A.,Roesler, J.,Romanowski, M.J. (deposition date: 2008-05-19, release date: 2010-03-02, Last modification date: 2024-10-16)

• Primary citation: Rosen-Wolff, A.,Romanowski, M.J.,Ritter, L.,Flecks, S.,Quoos, N.,Gramatt, J.,Petzold, C.,Nguyen, H.D.,Gahr, M.,Roesler, J.; Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever).; To be Published, 2008

Experimental method

X-RAY DIFFRACTION (2 Å)