3D6F

Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)

3D6F の概要

• エントリーDOI: 10.2210/pdb3d6f/pdb
• 関連するPDBエントリー: 1sc3 3d6h 3d6m
• 関連するBIRD辞書のPRD_ID: PRD_000338
• 分子名称: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide, ... (4 entities in total)
• 機能のキーワード: catalytic domain, naturally-occurring mutation, apoptosis, hydrolase, protease, thiol protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P29466 P29466
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 30833.82

構造登録者

Rosen-Wolff, A.,Roesler, J.,Romanowski, M.J. (登録日: 2008-05-19, 公開日: 2010-03-02, 最終更新日: 2023-08-30)

• 主引用文献: Rosen-Wolff, A.,Romanowski, M.J.,Ritter, L.,Flecks, S.,Quoos, N.,Gramatt, J.,Petzold, C.,Nguyen, H.D.,Gahr, M.,Roesler, J.; Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever).; To be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)