3D67

Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) in complex with 2-guanidino-ethyl-mercaptosuccinic acid (GEMSA)

3D67 の概要

• エントリーDOI: 10.2210/pdb3d67/pdb
• 関連するPDBエントリー: 3D66 3D68
• 分子名称: Carboxypeptidase B2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, alpha/beta hydrolase fold, carboxypeptidase, glycoprotein, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 149341.35

構造登録者

Brondijk, T.H.C.,Huizinga, E.G. (登録日: 2008-05-19, 公開日: 2008-07-01, 最終更新日: 2023-11-01)

• 主引用文献: Marx, P.F.,Brondijk, T.H.,Plug, T.,Romijn, R.A.,Hemrika, W.,Meijers, J.C.M.,Huizinga, E.G.; Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation; Blood, 112:2803-2809, 2008; PubMed: 18559974; DOI: 10.1182/blood-2008-03-146001

実験手法

X-RAY DIFFRACTION (3.4 Å)