3D66
Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
Summary for 3D66
| Entry DOI | 10.2210/pdb3d66/pdb |
| Related | 3D67 3D68 |
| Descriptor | Carboxypeptidase B2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION (3 entities in total) |
| Functional Keywords | alpha/beta hydrolase fold, carboxypeptidase, glycoprotein, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 148193.15 |
| Authors | Brondijk, T.H.C.,Huizinga, E.G. (deposition date: 2008-05-19, release date: 2008-07-01, Last modification date: 2023-11-01) |
| Primary citation | Marx, P.F.,Brondijk, T.H.,Plug, T.,Romijn, R.A.,Hemrika, W.,Meijers, J.C.M.,Huizinga, E.G. Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation Blood, 112:2803-2809, 2008 Cited by PubMed: 18559974DOI: 10.1182/blood-2008-03-146001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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