3D57

TR Variant D355R

3D57 の概要

• エントリーDOI: 10.2210/pdb3d57/pdb
• 分子名称: Thyroid hormone receptor beta, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: thyroid hormone receptor, ligand binding domain, d355r mutant, homodimer, alternative splicing, deafness, disease mutation, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, hormone, transcription receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P10828
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61595.48

構造登録者

Jouravel, N. (登録日: 2008-05-15, 公開日: 2008-10-14, 最終更新日: 2023-08-30)

• 主引用文献: Jouravel, N.,Sablin, E.,Togashi, M.,Baxter, J.D.,Webb, P.,Fletterick, R.J.; Molecular basis for dimer formation of TRbeta variant D355R.; Proteins, 75:111-117, 2008; PubMed: 18798561; DOI: 10.1002/prot.22225

実験手法

X-RAY DIFFRACTION (2.2 Å)