3D4Q

Pyrazole-based inhibitors of B-Raf kinase

Summary for 3D4Q

Entry DOI	10.2210/pdb3d4q/pdb
Related	3PSB 3PSD
Descriptor	B-Raf proto-oncogene serine/threonine-protein kinase, (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime (3 entities in total)
Functional Keywords	kinase, atp-binding, cardiomyopathy, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P15056
Total number of polymer chains	2
Total formula weight	71182.17
Authors	Morales, T.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2008-05-14, release date: 2008-08-19, Last modification date: 2024-02-21)
Primary citation	Hansen, J.D.,Grina, J.,Newhouse, B.,Welch, M.,Topalov, G.,Littman, N.,Callejo, M.,Gloor, S.,Martinson, M.,Laird, E.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Woessner, R.,Randolph, N.,Lyssikatos, J.,Olivero, A. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett., 18:4692-4695, 2008 Cited by PubMed: 18676143 DOI: 10.1016/j.bmcl.2008.07.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation