3D3P

Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor

3D3P の概要

• エントリーDOI: 10.2210/pdb3d3p/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: pde, phosphodiesterase, camp, alternative splicing, hydrolase, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41277.89

構造登録者

Somers, D.O.,Neu, M. (登録日: 2008-05-12, 公開日: 2009-05-19, 最終更新日: 2023-08-30)

• 主引用文献: Hamblin, J.N.,Angell, T.D.,Ballantine, S.P.,Cook, C.M.,Cooper, A.W.,Dawson, J.,Delves, C.J.,Jones, P.S.,Lindvall, M.,Lucas, F.S.,Mitchell, C.J.,Neu, M.Y.,Ranshaw, L.E.,Solanke, Y.E.,Somers, D.O.,Wiseman, J.O.; Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.; Bioorg.Med.Chem.Lett., 18:4237-4241, 2008; PubMed: 18539455; DOI: 10.1016/j.bmcl.2008.05.052

実験手法

X-RAY DIFFRACTION (1.75 Å)