3D3H

Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A

3D3H の概要

• エントリーDOI: 10.2210/pdb3d3h/pdb
• 関連するPDBエントリー: 2OQO
• 分子名称: Penicillin-insensitive transglycosylase, (2R)-3-{[(S)-{[(2R,3R,4R,5S,6S)-3-{[(2S,3R,4R,5S,6R)-3-(acetylamino)-5-{[(2S,3R,4R,5S,6R)-3-(acetylamino)-5-{[(2R,3R,4S,5R,6S)-6-carbamoyl-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-6-carbamoyl-4-(carbamoyloxy)-5-hydroxy-5-methyltetrahydro-2H-pyran-2-yl]oxy}(hydroxy)phosphoryl]oxy}-2-{[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]oxy}propanoic acid (3 entities in total)
• 機能のキーワード: peptidoglycan glycosyltransferase, cell wall biosynthesis, antibiotics, penicillin-binding protein, transglycosylase, moenomycin, antibiotic resistance, cell shape, cell wall biogenesis/degradation, hydrolase, inner membrane, membrane, multifunctional enzyme, peptidoglycan synthesis, signal-anchor, transmembrane, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Aquifex aeolicus
• 細胞内の位置: Cell inner membrane; Single-pass type II membrane protein (By similarity): O66874
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24194.58

構造登録者

Yuan, Y.,Sliz, P.,Walker, S. (登録日: 2008-05-11, 公開日: 2008-07-22, 最終更新日: 2023-08-30)

• 主引用文献: Yuan, Y.,Fuse, S.,Ostash, B.,Sliz, P.,Kahne, D.,Walker, S.; Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design.; Acs Chem.Biol., 3:429-436, 2008; PubMed: 18642800; DOI: 10.1021/cb800078a

実験手法

X-RAY DIFFRACTION (2.31 Å)