3D32

Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide

3D32 の概要

• エントリーDOI: 10.2210/pdb3d32/pdb
• 分子名称: Gamma-aminobutyric acid receptor-associated protein, K1 peptide, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: alpha-beta, beta-grasp fold, cytoskeleton, golgi apparatus, membrane, microtubule, transport, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 31456.17

構造登録者

Weiergraeber, O.H.,Stangler, T.,Willbold, D. (登録日: 2008-05-09, 公開日: 2008-08-05, 最終更新日: 2024-11-13)

主引用文献

Weiergraber, O.H.,Stangler, T.,Thielmann, Y.,Mohrluder, J.,Wiesehan, K.,Willbold, D.
Ligand Binding Mode of GABA(A) Receptor-Associated Protein.
J.Mol.Biol., 381:1320-1331, 2008

PubMed Abstract: The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

PubMed: 18638487
DOI: 10.1016/j.jmb.2008.06.086

実験手法

X-RAY DIFFRACTION (1.3 Å)