3D2K

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid

Summary for 3D2K

• Entry DOI: 10.2210/pdb3d2k/pdb
• Related: 3d14 3d15 3d2i
• Descriptor: serine/threonine kinase 6, (7-{[2-(2-{[(3-chlorophenyl)carbamoyl]amino}-1,3-thiazol-5-yl)ethyl]amino}-1H-pyrazolo[4,3-d]pyrimidin-1-yl)acetic acid (3 entities in total)
• Functional Keywords: aurora a, small-molecule inhibitor, kinase, transferase
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 1
• Total formula weight: 32022.08

Authors

Elling, R.A.,Oslob, J.D.,Yu, C.,Romanowski, M.J. (deposition date: 2008-05-08, release date: 2009-05-12, Last modification date: 2023-08-30)

• Primary citation: Oslob, J.D.,Yu, C.,Allen, D.A.,Baskaran, S.,Maung, J.,Michelotti, E.F.,Elling, R.A.,Romanowski, M.J.; Discovery of Aurora-A-selective inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)