3D25
Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC HLA-A2
Summary for 3D25
Entry DOI | 10.2210/pdb3d25/pdb |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Nonameric peptide from HA-1, ... (4 entities in total) |
Functional Keywords | mhc, hla-a2, secondary anchor residue, glycoprotein, immune system, minor histocompatibility antigen, stem cell transplantation, immune response |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 |
Total number of polymer chains | 3 |
Total formula weight | 44385.22 |
Authors | Nicholls, S.,Piper, K.P.,Mohammed, F.,Dafforn, T.R.,Tenzer, S.,Salim, M.,Mahendra, P.,Craddock, C.,van Endert, P.,Schild, H.,Cobbold, M.,Engelhard, V.H.,Moss, P.A.H.,Willcox, B.E. (deposition date: 2008-05-07, release date: 2009-02-10, Last modification date: 2023-08-30) |
Primary citation | Nicholls, S.,Piper, K.P.,Mohammed, F.,Dafforn, T.R.,Tenzer, S.,Salim, M.,Mahendra, P.,Craddock, C.,van Endert, P.,Schild, H.,Cobbold, M.,Engelhard, V.H.,Moss, P.A.,Willcox, B.E. Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition Proc.Natl.Acad.Sci.USA, 106:3889-3894, 2009 Cited by PubMed: 19234124DOI: 10.1073/pnas.0900411106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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