3D14

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea

3D14 の概要

• エントリーDOI: 10.2210/pdb3d14/pdb
• 関連するPDBエントリー: 1mq4 3D15
• 分子名称: serine/threonine kinase 6, 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
• 機能のキーワード: aurora a, small-molecule inhibitor, kinase, transferase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32013.66

構造登録者

Elling, R.A.,Baskaran, S.,Allen, D.A.,Oslob, J.D.,Romanowski, M.J. (登録日: 2008-05-04, 公開日: 2008-08-26, 最終更新日: 2023-08-30)

• 主引用文献: Oslob, J.D.,Romanowski, M.J.,Allen, D.A.,Baskaran, S.,Bui, M.,Elling, R.A.,Flanagan, W.M.,Fung, A.D.,Hanan, E.J.,Harris, S.,Heumann, S.A.,Hoch, U.,Jacobs, J.W.,Lam, J.,Lawrence, C.E.,McDowell, R.S.,Nannini, M.A.,Shen, W.,Silverman, J.A.,Sopko, M.M.,Tangonan, B.T.,Teague, J.,Yoburn, J.C.,Yu, C.H.,Zhong, M.,Zimmerman, K.M.,O'Brien, T.,Lew, W.; Discovery of a potent and selective aurora kinase inhibitor.; Bioorg.Med.Chem.Lett., 18:4880-4884, 2008; PubMed: 18678489; DOI: 10.1016/j.bmcl.2008.07.073

実験手法

X-RAY DIFFRACTION (1.9 Å)