3D0B

Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90

3D0B の概要

• エントリーDOI: 10.2210/pdb3d0b/pdb
• 分子名称: Heat shock protein HSP 90-alpha, 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide (3 entities in total)
• 機能のキーワード: hsp90, heat shock protein 90, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26534.82

構造登録者

Barta, T.E.,Veal, J.M.,Huang, K.H.,Hall, S.H. (登録日: 2008-05-01, 公開日: 2008-06-17, 最終更新日: 2024-04-10)

• 主引用文献: Barta, T.E.,Veal, J.M.,Rice, J.W.,Partridge, J.M.,Fadden, R.P.,Ma, W.,Jenks, M.,Geng, L.,Hanson, G.J.,Huang, K.H.,Barabasz, A.F.,Foley, B.E.,Otto, J.,Hall, S.E.; Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90; BIOORG.MED.CHEM.LETT., 18:3517-3521, 2008; PubMed: 18511277; DOI: 10.1016/j.bmcl.2008.05.023

実験手法

X-RAY DIFFRACTION (1.74 Å)