3CZY

Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(Adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone

3CZY の概要

• エントリーDOI: 10.2210/pdb3czy/pdb
• 分子名称: Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone, ... (4 entities in total)
• 機能のキーワード: heme oxygenase-1 inhibitor complex, endoplasmic reticulum, heme, iron, metal-binding, microsome, oxidoreductase, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Microsome: P09601
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55518.87

構造登録者

Jia, Z.,Rahman, M.N. (登録日: 2008-04-30, 公開日: 2008-09-30, 最終更新日: 2023-08-30)

• 主引用文献: Rahman, M.N.,Vlahakis, J.Z.,Szarek, W.A.,Nakatsu, K.,Jia, Z.; X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.; J.Med.Chem., 51:5943-5952, 2008; PubMed: 18798608; DOI: 10.1021/jm800505m

実験手法

X-RAY DIFFRACTION (1.54 Å)