3CXF

Crystal structure of transthyretin variant Y114H

Summary for 3CXF

Entry DOI	10.2210/pdb3cxf/pdb
Related	1F41 2G4E 2NOY 3BSZ 3BT0
Descriptor	Transthyretin (2 entities in total)
Functional Keywords	ttr, amyloid fibrils, point mutation, transport protein, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	27504.67
Authors	Cendron, L.,Zanotti, G.,Folli, C.,Alfieri, B.,Pasquato, N.,Berni, R. (deposition date: 2008-04-24, release date: 2009-04-07, Last modification date: 2023-11-01)
Primary citation	Zanotti, G.,Folli, C.,Cendron, L.,Alfieri, B.,Nishida, S.K.,Gliubich, F.,Pasquato, N.,Negro, A.,Berni, R. Structural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding protein. Febs J., 275:5841-5854, 2008 Cited by PubMed: 19021760 DOI: 10.1111/j.1742-4658.2008.06705.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation