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3CWM

Crystal structure of alpha-1-antitrypsin complexed with citrate

Summary for 3CWM
Entry DOI10.2210/pdb3cwm/pdb
Related3CWL
DescriptorAlpha-1-antitrypsin, CITRIC ACID (3 entities in total)
Functional Keywordsantitrypsin, polymerisation, protein aggregation, protein unfolding, serpin, acute phase, disease mutation, glycoprotein, protease inhbitor, secreted, serine protease inhibitor, blood coagulation, protease inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationSecreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009
Total number of polymer chains1
Total formula weight44602.48
Authors
Morton, C.J.,Hansen, G.,Feil, S.C.,Adams, J.J.,Parker, M.W. (deposition date: 2008-04-22, release date: 2008-09-23, Last modification date: 2017-10-25)
Primary citationPearce, M.C.,Morton, C.J.,Feil, S.C.,Hansen, G.,Adams, J.J.,Parker, M.W.,Bottomley, S.P.
Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17:2127-2133, 2008
Cited by
PubMed: 18780818
DOI: 10.1110/ps.037234.108
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.51 Å)
Structure validation

217705

数据于2024-03-27公开中

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