3CWB

Chicken Cytochrome BC1 Complex inhibited by an iodinated analogue of the polyketide Crocacin-D

3CWB の概要

• エントリーDOI: 10.2210/pdb3cwb/pdb
• 分子名称: MITOCHONDRIAL UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN I, MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE 7.2 KDA PROTEIN, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (21 entities in total)
• 機能のキーワード: crocacin d, inhibitor design, structure-activity relationship, polyketide, fungicide, cytochrome bc1, membrane protein, heme protein, rieske iron sulfur protein, cytochrome b, cytochrome c1, complex iii, mitochondrial processing protea ubiquinone, oxidoreductase, redox enzyme, respiratory chain, electron transport, heme, inner membrane, iron, membrane, metal-binding, mitochondrion, transmembrane, transport
• 由来する生物種: Gallus gallus (chicken); 詳細
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 481896.65

構造登録者

Huang, L.,Cromartie, T.,Viner, R.,Crowley, P.J.,Berry, E.A. (登録日: 2008-04-21, 公開日: 2008-08-12, 最終更新日: 2023-08-30)

• 主引用文献: Crowley, P.J.,Berry, E.A.,Cromartie, T.,Daldal, F.,Godfrey, C.R.,Lee, D.W.,Phillips, J.E.,Taylor, A.,Viner, R.; The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.; Bioorg.Med.Chem., 16:10345-10355, 2008; PubMed: 18996700; DOI: 10.1016/j.bmc.2008.10.030

実験手法

X-RAY DIFFRACTION (3.51 Å)