3CV6

The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.

Summary for 3CV6

Entry DOI	10.2210/pdb3cv6/pdb
Descriptor	Aldo-keto reductase family 1 member C21, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, ... (5 entities in total)
Functional Keywords	aldo-keto reductase, hydroxysteroid dehydrogenase, ternary complex, hexestrol, lipid metabolism, nadp, oxidoreductase, phosphoprotein, steroid metabolism
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	76427.62
Authors	Dhagat, U.,El-Kabbani, O. (deposition date: 2008-04-17, release date: 2009-03-03, Last modification date: 2023-11-01)
Primary citation	Dhagat, U.,Endo, S.,Mamiya, H.,Hara, A.,El-Kabbani, O. Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate. Acta Crystallogr.,Sect.D, 65:257-265, 2009 Cited by PubMed: 19237748 DOI: 10.1107/S0907444908044028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation