3CV6

The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.

3CV6 の概要

• エントリーDOI: 10.2210/pdb3cv6/pdb
• 分子名称: Aldo-keto reductase family 1 member C21, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, ... (5 entities in total)
• 機能のキーワード: aldo-keto reductase, hydroxysteroid dehydrogenase, ternary complex, hexestrol, lipid metabolism, nadp, oxidoreductase, phosphoprotein, steroid metabolism
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76427.62

構造登録者

Dhagat, U.,El-Kabbani, O. (登録日: 2008-04-17, 公開日: 2009-03-03, 最終更新日: 2023-11-01)

• 主引用文献: Dhagat, U.,Endo, S.,Mamiya, H.,Hara, A.,El-Kabbani, O.; Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.; Acta Crystallogr.,Sect.D, 65:257-265, 2009; PubMed: 19237748; DOI: 10.1107/S0907444908044028

実験手法

X-RAY DIFFRACTION (2.1 Å)