3CUT

Crystal structure of glycogen phosphorylase b in complex with N-(-D-glucopyranosyl)-N'-(2-naphthyl)oxamide

3CUT の概要

• エントリーDOI: 10.2210/pdb3cut/pdb
• 関連するPDBエントリー: 3CUU 3CUV 3CUW
• 分子名称: Glycogen phosphorylase, muscle form, N-[(naphthalen-2-ylamino)(oxo)acetyl]-beta-D-glucopyranosylamine (3 entities in total)
• 機能のキーワード: glycogen phosphorylase, catalytic site, rational inhibitor design, acetylation, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97895.68

構造登録者

Kyritsi, C.,Chrysina, E.D.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G. (登録日: 2008-04-17, 公開日: 2009-04-21, 最終更新日: 2023-11-15)

• 主引用文献: Czifrak, K.,Kyritsi, C.,Felfoldi, N.,Dosca, T.,Gergely, P.,Chrysina, E.D.,Siafaka-Kapadai, A.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.; Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides; To be Published,

実験手法

X-RAY DIFFRACTION (2.3 Å)