3CUK

Crystal structure of human D-amino acid oxidase: bound to an inhibitor

3CUK の概要

• エントリーDOI: 10.2210/pdb3cuk/pdb
• 分子名称: D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 4H-furo[3,2-b]pyrrole-5-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, alpha-beta-alpha motif, flavin containing proteinalpha-beta-alpha motif, flavin containing protein, fad, flavoprotein, peroxisome
• 由来する生物種: Homo sapiens
• 細胞内の位置: Peroxisome: P14920
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161830.32

構造登録者

Prasad, S.,Munshi, S. (登録日: 2008-04-16, 公開日: 2008-07-22, 最終更新日: 2023-08-30)

主引用文献

Sparey, T.,Abeywickrema, P.,Almond, S.,Brandon, N.,Byrne, N.,Campbell, A.,Hutson, P.H.,Jacobson, M.,Jones, B.,Munshi, S.,Pascarella, D.,Pike, A.,Prasad, G.S.,Sachs, N.,Sakatis, M.,Sardana, V.,Venkatraman, S.,Young, M.B.
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg.Med.Chem.Lett., 18:3386-3391, 2008

PubMed Abstract: The 'NMDA hypofunction hypothesis of schizophrenia' can be tested in a number of ways. DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the NMDA receptor. We identified novel DAO inhibitors, in particular, acid 1, which demonstrated moderate potency for DAO in vitro and ex vivo, and raised plasma d-serine levels after dosing ip to rats. In parallel, analogues were prepared to survey the SARs of 1.

PubMed: 18455394
DOI: 10.1016/j.bmcl.2008.04.020

実験手法

X-RAY DIFFRACTION (2.49 Å)