3CTQ
Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide
Summary for 3CTQ
Entry DOI | 10.2210/pdb3ctq/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-benzyl-1-[5-({5-tert-butyl-2-methoxy-3-[(methylsulfonyl)amino]phenyl}carbamoyl)-2-methylphenyl]-1H-1,2,3-triazole-4-carboxamide (3 entities in total) |
Functional Keywords | two lobe kinase fold, n-terminal beta-sheet, c-terminal alpha-helix, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (man) |
Cellular location | Cytoplasm: Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 40391.28 |
Authors | Qian, K. (deposition date: 2008-04-14, release date: 2008-05-27, Last modification date: 2024-02-21) |
Primary citation | Cogan, D.A.,Aungst, R.,Breinlinger, E.C.,Fadra, T.,Goldberg, D.R.,Hao, M.H.,Kroe, R.,Moss, N.,Pargellis, C.,Qian, K.C.,Swinamer, A.D. Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 18:3251-3255, 2008 Cited by PubMed: 18462940DOI: 10.1016/j.bmcl.2008.04.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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