3CSO
HCV Polymerase in complex with a 1,5 Benzodiazepine inhibitor
Summary for 3CSO
Entry DOI | 10.2210/pdb3cso/pdb |
Related | 1nb4 |
Descriptor | RNA-directed RNA polymerase, (11S)-10-acetyl-11-[4-(benzyloxy)-3-chlorophenyl]-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (3 entities in total) |
Functional Keywords | 1, 5-benzodiazepines, hepatitis c virus, ns5b, polymerase, transferase |
Biological source | Hepatitis C virus isolate |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
Total number of polymer chains | 2 |
Total formula weight | 130636.56 |
Authors | Nyanguile, O. (deposition date: 2008-04-10, release date: 2009-04-14, Last modification date: 2024-02-21) |
Primary citation | Nyanguile, O.,Pauwels, F.,Van den Broeck, W.,Boutton, C.W.,Quirynen, L.,Ivens, T.,van der Helm, L.,Vandercruyssen, G.,Mostmans, W.,Delouvroy, F.,Dehertogh, P.,Cummings, M.D.,Bonfanti, J.F.,Simmen, K.A.,Raboisson, P. 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. Antimicrob.Agents Chemother., 52:4420-4431, 2008 Cited by PubMed: 18852280DOI: 10.1128/AAC.00669-08 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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