3CSE

Candida glabrata Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

3CSE の概要

• エントリーDOI: 10.2210/pdb3cse/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, reductase, oxidoreductase
• 由来する生物種: Candida glabrata (yeast)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54970.24

構造登録者

Liu, J.,Anderson, A.C. (登録日: 2008-04-09, 公開日: 2008-11-25, 最終更新日: 2024-02-21)

• 主引用文献: Liu, J.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C.; Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.; Chem.Biol., 15:990-996, 2008; PubMed: 18804036; DOI: 10.1016/j.chembiol.2008.07.013

実験手法

X-RAY DIFFRACTION (1.6 Å)