3CPU
SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Summary for 3CPU
Entry DOI | 10.2210/pdb3cpu/pdb |
Related PRD ID | PRD_900001 |
Descriptor | Pancreatic alpha-amylase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | amylase, acarbose, mutagenesis, diabetes, catalysis, pancreatic, enzyme, human, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 56348.15 |
Authors | Brayer, G.D.,Sidhu, G.,Maurus, R.,Rydberg, E.H.,Braun, C.,Wang, Y.,Nguyen, N.T.,Overall, C.M.,Withers, S.G. (deposition date: 1999-06-08, release date: 2001-06-30, Last modification date: 2023-12-27) |
Primary citation | Brayer, G.D.,Sidhu, G.,Maurus, R.,Rydberg, E.H.,Braun, C.,Wang, Y.,Nguyen, N.T.,Overall, C.M.,Withers, S.G. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39:4778-4791, 2000 Cited by PubMed: 10769135DOI: 10.1021/bi9921182 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)