3CP1
Structure of a longer thermalstable core domain of HIV-1 gp41 containing the enfuvirtide resistance mutation N43D
3CP1 の概要
エントリーDOI | 10.2210/pdb3cp1/pdb |
分子名称 | Transmembrane Protein (2 entities in total) |
機能のキーワード | hiv-1 envelope glycoprotein, 6-helix bundle, gp41, n43d, aids, apoptosis, coiled coil, envelope protein, fusion protein, host-virus interaction, membrane, transmembrane, virion, viral protein |
由来する生物種 | Human immunodeficiency virus 1 詳細 |
細胞内の位置 | Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : Q70626 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 9975.12 |
構造登録者 | |
主引用文献 | Bai, X.,Wilson, K.L.,Seedorff, J.E.,Ahrens, D.,Green, J.,Davison, D.K.,Jin, L.,Stanfield-Oakley, S.A.,Mosier, S.M.,Melby, T.E.,Cammack, N.,Wang, Z.,Greenberg, M.L.,Dwyer, J.J. Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Biochemistry, 47:6662-6670, 2008 Cited by PubMed: 18507398DOI: 10.1021/bi702509d 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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