3COT

Crystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A.

3COT の概要

• エントリーDOI: 10.2210/pdb3cot/pdb
• 関連するPDBエントリー: 3CMF
• 分子名称: 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (4 entities in total)
• 機能のキーワード: steroid c-c double bond reduction, 5beta reductase, e120, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, nadp, oxidoreductase, steroid metabolism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P51857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81314.25

構造登録者

Di Costanzo, L.,Drury, J.,Penning, T.M.,Christianson, D.W. (登録日: 2008-03-29, 公開日: 2008-04-08, 最終更新日: 2023-08-30)

• 主引用文献: Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W.; Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis.; J.Biol.Chem., 283:16830-16839, 2008; PubMed: 18407998; DOI: 10.1074/jbc.M801778200

実験手法

X-RAY DIFFRACTION (2.03 Å)