3CO8

Crystal structure of alanine racemase from Oenococcus oeni

3CO8 の概要

• エントリーDOI: 10.2210/pdb3co8/pdb
• 分子名称: Alanine racemase, PYRIDOXAL-5'-PHOSPHATE (3 entities in total)
• 機能のキーワード: alanine racemase, protein structure initiative ii, psi-ii, nysgxrc, 11082i, plp, tim barrel, structural genomics, new york sgx research center for structural genomics, isomerase, pyridoxal phosphate
• 由来する生物種: Oenococcus oeni
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 86387.38

構造登録者

Palani, K.,Burley, S.K.,Swaminathan, S.,New York SGX Research Center for Structural Genomics (NYSGXRC) (登録日: 2008-03-27, 公開日: 2008-04-08, 最終更新日: 2025-03-26)

主引用文献

Palani, K.,Burley, S.K.,Swaminathan, S.
Structure of alanine racemase from Oenococcus oeni with bound pyridoxal 5'-phosphate.
Acta Crystallogr.,Sect.F, 69:15-19, 2013

PubMed Abstract: The crystal structure of alanine racemase from Oenococcus oeni has been determined at 1.7 Å resolution using the single-wavelength anomalous dispersion (SAD) method and selenium-labelled protein. The protein exists as a symmetric dimer in the crystal, with both protomers contributing to the two active sites. Pyridoxal 5'-phosphate, a cofactor, is bound to each monomer and forms a Schiff base with Lys39. Structural comparison of alanine racemase from O. oeni (Alr) with homologous family members revealed similar domain organization and cofactor binding.

PubMed: 23295479
DOI: 10.1107/S1744309112047276

実験手法

X-RAY DIFFRACTION (1.7 Å)