3CLB

Structure of bifunctional TcDHFR-TS in complex with TMQ

Summary for 3CLB

Entry DOI	10.2210/pdb3clb/pdb
Related	2H2Q 3CL9
Descriptor	DHFR-TS, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	bifunctional enzyme in complex with nadp and tmq, oxidoreductase-transferase complex, oxidoreductase, transferase
Biological source	Trypanosoma cruzi
Total number of polymer chains	4
Total formula weight	240828.28
Authors	Schormann, N.,Senkovich, O.,Chattopadhyay, D. (deposition date: 2008-03-18, release date: 2009-01-06, Last modification date: 2023-08-30)
Primary citation	Schormann, N.,Senkovich, O.,Walker, K.,Wright, D.L.,Anderson, A.C.,Rosowsky, A.,Ananthan, S.,Shinkre, B.,Velu, S.,Chattopadhyay, D. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73:889-901, 2008 Cited by PubMed: 18536013 DOI: 10.1002/prot.22115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation