3CH6

Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone

3CH6 の概要

• エントリーDOI: 10.2210/pdb3ch6/pdb
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone, ... (4 entities in total)
• 機能のキーワード: 11b-hsd1, sdr, dehydrogenase, hydroxysteroid, inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129664.64

構造登録者

Sheriff, S. (登録日: 2008-03-07, 公開日: 2008-06-10, 最終更新日: 2024-04-03)

• 主引用文献: Wang, H.,Ruan, Z.,Li, J.J.,Simpkins, L.M.,Smirk, R.A.,Wu, S.C.,Hutchins, R.D.,Nirschl, D.S.,Van Kirk, K.,Cooper, C.B.,Sutton, J.C.,Ma, Z.,Golla, R.,Seethala, R.,Salyan, M.E.,Nayeem, A.,Krystek, S.R.,Sheriff, S.,Camac, D.M.,Morin, P.E.,Carpenter, B.,Robl, J.A.,Zahler, R.,Gordon, D.A.,Hamann, L.G.; Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1; Bioorg.Med.Chem.Lett., 18:3168-3172, 2008; PubMed: 18485702; DOI: 10.1016/j.bmcl.2008.04.069

実験手法

X-RAY DIFFRACTION (2.35 Å)