3CF6

Structure of Epac2 in complex with cyclic-AMP and Rap

3CF6 の概要

• エントリーDOI: 10.2210/pdb3cf6/pdb
• 関連するPDBエントリー: 2BYV
• 分子名称: Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, ... (5 entities in total)
• 機能のキーワード: epac, rapgef4, rap, rap1b, camp, sp-camps, gef, gunanine nucleotide exchange factor, g-protein, gtp-binding, nucleotide-binding, signaling protein regulator-gtp-binding protein complex, signaling protein-gtp-binding protein complex, signaling protein/gtp-binding protein
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Cell membrane: P61224
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99084.95

構造登録者

Rehmann, H.,Arias-Palomo, E.,Hadders, M.A.,Schwede, F.,Llorca, O.,Bos, J.L. (登録日: 2008-03-02, 公開日: 2008-07-29, 最終更新日: 2023-11-01)

• 主引用文献: Rehmann, H.,Arias-Palomo, E.,Hadders, M.A.,Schwede, F.,Llorca, O.,Bos, J.L.; Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B; Nature, 455:124-127, 2008; PubMed: 18660803; DOI: 10.1038/nature07187

実験手法

X-RAY DIFFRACTION (2.2 Å)