3CEN

Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide

3CEN の概要

• エントリーDOI: 10.2210/pdb3cen/pdb
• 分子名称: COAGULATION FACTOR X, HEAVY CHAIN, COAGULATION FACTOR X, LIGHT CHAIN, N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE, ... (4 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, hydroxylation, polymorphism, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32517.26

構造登録者

Chang, C.-H. (登録日: 2008-02-29, 公開日: 2008-05-20, 最終更新日: 2011-07-13)

• 主引用文献: Corte, J.R.,Fang, T.,Pinto, D.J.P.,Han, W.,Hu, Z.,Jiang, X.-J.,Li, Y.-L.,Gauuan, J.F.,Hadden, M.,Orton, D.,Rendina, A.R.,Luettgen, J.M.,Wong, P.C.,He, K.,Morin, P.,Chang, C.-H.,Cheney, D.L.,Knabb, R.M.,Wexler, R.R.,Lam, P.Y.S.; Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties; Bioorg.Med.Chem.Lett., 18:2845-2849, 2008; PubMed: 18424044; DOI: 10.1016/j.bmcl.2008.03.092

実験手法

X-RAY DIFFRACTION (1.6 Å)