3CEN

Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide

3CEN の概要

• エントリーDOI: 10.2210/pdb3cen/pdb
• 分子名称: COAGULATION FACTOR X, HEAVY CHAIN, COAGULATION FACTOR X, LIGHT CHAIN, N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE, ... (4 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, hydroxylation, polymorphism, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32517.26

構造登録者

Chang, C.-H. (登録日: 2008-02-29, 公開日: 2008-05-20, 最終更新日: 2024-10-30)

主引用文献

Corte, J.R.,Fang, T.,Pinto, D.J.P.,Han, W.,Hu, Z.,Jiang, X.-J.,Li, Y.-L.,Gauuan, J.F.,Hadden, M.,Orton, D.,Rendina, A.R.,Luettgen, J.M.,Wong, P.C.,He, K.,Morin, P.,Chang, C.-H.,Cheney, D.L.,Knabb, R.M.,Wexler, R.R.,Lam, P.Y.S.
Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties
Bioorg.Med.Chem.Lett., 18:2845-2849, 2008

PubMed Abstract: Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.

PubMed: 18424044
DOI: 10.1016/j.bmcl.2008.03.092

実験手法

X-RAY DIFFRACTION (1.6 Å)