3CEM

Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE9423

3CEM の概要

• エントリーDOI: 10.2210/pdb3cem/pdb
• 関連するPDBエントリー: 3ceh 3cej
• 分子名称: Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: protein ligand complex, tense state, allosteric inhibitor, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 188074.38

構造登録者

Wendt, K.U.,Dreyer, M.K.,Anderka, O.,Klabunde, T.,Loenze, P.,Defossa, E.,Schmoll, D. (登録日: 2008-02-29, 公開日: 2008-05-27, 最終更新日: 2020-07-29)

• 主引用文献: Anderka, O.,Loenze, P.,Klabunde, T.,Dreyer, M.K.,Defossa, E.,Wendt, K.U.,Schmoll, D.; Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors.; Biochemistry, 47:4683-4691, 2008; PubMed: 18373353; DOI: 10.1021/bi702397d

実験手法

X-RAY DIFFRACTION (2.47 Å)