3CE3
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor
Summary for 3CE3
Entry DOI | 10.2210/pdb3ce3/pdb |
Related | 3C1X |
Descriptor | Hepatocyte growth factor receptor, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35893.45 |
Authors | Sack, J. (deposition date: 2008-02-28, release date: 2008-08-26, Last modification date: 2024-02-21) |
Primary citation | Kim, K.S.,Zhang, L.,Schmidt, R.,Cai, Z.W.,Wei, D.,Williams, D.K.,Lombardo, L.J.,Trainor, G.L.,Xie, D.,Zhang, Y.,An, Y.,Sack, J.S.,Tokarski, J.S.,Darienzo, C.,Kamath, A.,Marathe, P.,Zhang, Y.,Lippy, J.,Jeyaseelan, R.,Wautlet, B.,Henley, B.,Gullo-Brown, J.,Manne, V.,Hunt, J.T.,Fargnoli, J.,Borzilleri, R.M. Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities. J.Med.Chem., 51:5330-5341, 2008 Cited by PubMed: 18690676DOI: 10.1021/jm800476q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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