3CDS

Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue)

3CDS の概要

• エントリーDOI: 10.2210/pdb3cds/pdb
• 関連するPDBエントリー: 1K74 3CDP
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid (3 entities in total)
• 機能のキーワード: bundle of alpha-helices and a small four-stranded beta-sheet, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65331.63

構造登録者

Pochetti, G.,Montanari, R.,Mazza, F. (登録日: 2008-02-27, 公開日: 2008-12-30, 最終更新日: 2024-03-13)

• 主引用文献: Montanari, R.,Saccoccia, F.,Scotti, E.,Crestani, M.,Godio, C.,Gilardi, F.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Tortorella, P.,Lavecchia, A.,Novellino, E.,Mazza, F.,Aschi, M.,Pochetti, G.; Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design; J.Med.Chem., 51:7768-7776, 2008; PubMed: 19053776; DOI: 10.1021/jm800733h

実験手法

X-RAY DIFFRACTION (2.65 Å)