3CDP

Crystal structure of PPAR-gamma LBD complexed with a partial agonist, analogue of clofibric acid

3CDP の概要

• エントリーDOI: 10.2210/pdb3cdp/pdb
• 関連するPDBエントリー: 1K74 3CDS
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid (3 entities in total)
• 機能のキーワード: bundle of alpha-helices and a small four-stranded beta-sheet, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65338.02

構造登録者

Pochetti, G.,Montanari, R.,Mazza, F. (登録日: 2008-02-27, 公開日: 2009-01-13, 最終更新日: 2024-03-13)

• 主引用文献: Fracchiolla, G.,Laghezza, A.,Piemontese, L.,Parente, M.,Lavecchia, A.,Pochetti, G.,Montanari, R.,Di Giovanni, C.,Carbonara, G.,Tortorella, P.,Novellino, E.,Loiodice, F.; Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists; Bioorg.Med.Chem., 20:2141-2151, 2012; PubMed: 22341573; DOI: 10.1016/j.bmc.2012.01.025

実験手法

X-RAY DIFFRACTION (2.8 Å)