3CDM

Structural adaptation and conservation in quadruplex-drug recognition

Summary for 3CDM

• Entry DOI: 10.2210/pdb3cdm/pdb
• Related: 3CCO
• Descriptor: DNA (5'-D(*DT*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DG)-3'), 2,7-bis[3-(dimethylamino)propyl]-4,9-bis[(3-hydroxypropyl)amino]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: quadruplex, dna, propeller, intramolecular, human telomere parallel stranded, ligand, complex
• Total number of polymer chains: 2
• Total formula weight: 18227.92

Authors

Parkinson, G.N.,Neidle, S. (deposition date: 2008-02-27, release date: 2008-09-23, Last modification date: 2023-11-01)

• Primary citation: Parkinson, G.N.,Cuenca, F.,Neidle, S.; Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes; J.Mol.Biol., 381:1145-1156, 2008; PubMed: 18619463; DOI: 10.1016/j.jmb.2008.06.022

Experimental method

X-RAY DIFFRACTION (2.1 Å)