3CAS
Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 4-androstenedione
Summary for 3CAS
Entry DOI | 10.2210/pdb3cas/pdb |
Related | 3CAQ 3CAV |
Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, BETA-MERCAPTOETHANOL, ... (6 entities in total) |
Functional Keywords | 5b-reductase, 5beta-reductase, 5b-red, akr1d1, akr, aldo-keto reductase, nadp, androstenedione, nadph, substrate inhibition, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P51857 |
Total number of polymer chains | 2 |
Total formula weight | 77365.96 |
Authors | Faucher, F.,Cantin, L.,Breton, R. (deposition date: 2008-02-20, release date: 2008-12-09, Last modification date: 2024-02-21) |
Primary citation | Faucher, F.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger). Biochemistry, 47:13537-13546, 2008 Cited by PubMed: 19075558DOI: 10.1021/bi801276h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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