3C7Q

Structure of VEGFR2 kinase domain in complex with BIBF1120

Summary for 3C7Q

• Entry DOI: 10.2210/pdb3c7q/pdb
• Descriptor: Vascular endothelial growth factor receptor 2, SULFATE ION, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, ... (4 entities in total)
• Functional Keywords: alpha beta, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 1
• Total formula weight: 37576.93

Authors

Hilberg, F.,Roth, G.J.,Krssak, M.,Kautschitsch, S.,Sommergruber, W.,Tontsch-Grunt, U.,Garin-Chesa, P.,Bader, G.,Zoephel, A.,Quant, J.,Heckel, A.,Rettig, W.J. (deposition date: 2008-02-08, release date: 2008-12-23, Last modification date: 2023-11-15)

• Primary citation: Hilberg, F.,Roth, G.J.,Krssak, M.,Kautschitsch, S.,Sommergruber, W.,Tontsch-Grunt, U.,Garin-Chesa, P.,Bader, G.,Zoephel, A.,Quant, J.,Heckel, A.,Rettig, W.J.; BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.; Cancer Res., 68:4774-4782, 2008; PubMed: 18559524; DOI: 10.1158/0008-5472.CAN-07-6307

Experimental method

X-RAY DIFFRACTION (2.1 Å)