3C4U

Structure of class II fructose-biphosphate aldolase from helicobacter pylori

Summary for 3C4U

• Entry DOI: 10.2210/pdb3c4u/pdb
• Related: 3C52 3C56
• Descriptor: Fructose-bisphosphate aldolase, SODIUM ION, ZINC ION, ... (4 entities in total)
• Functional Keywords: fbp aldolase, class ii, zinc, glycolysis, lyase, metal-binding
• Biological source: Helicobacter pylori (Campylobacter pylori)
• Total number of polymer chains: 2
• Total formula weight: 67778.42

Authors

Coincon, M.,Sygusch, J. (deposition date: 2008-01-30, release date: 2008-08-26, Last modification date: 2023-08-30)

Primary citation

Fonvielle, M.,Coincon, M.,Daher, R.,Desbenoit, N.,Kosieradzka, K.,Barilone, N.,Gicquel, B.,Sygusch, J.,Jackson, M.,Therisod, M.
Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.
Chemistry, 14:8521-8529, 2008

PubMed Abstract: We report the synthesis and biochemical evaluation of selective inhibitors of class II (zinc-dependent) fructose bisphosphate aldolases. The most active compound is a simplified analogue of fructose bisphosphate, bearing a well-positioned metal chelating group. It is a powerful and highly selective competitive inhibitor of isolated class II aldolases. We report crystallographic studies of this inhibitor bound in the active site of the Helicobacter pylori enzyme. The compound also shows activity against Mycobacterium tuberculosis isolates.

PubMed: 18688832
DOI: 10.1002/chem.200800857

Experimental method

X-RAY DIFFRACTION (1.83 Å)