3C3U

Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid

3C3U の概要

• エントリーDOI: 10.2210/pdb3c3u/pdb
• 分子名称: Aldo-keto reductase family 1 member C1, ZINC ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: aldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, akr1c1, cytoplasm, nadp, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q04828
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37855.16

構造登録者

Dhagat, U.,El-Kabbani, O. (登録日: 2008-01-28, 公開日: 2008-08-26, 最終更新日: 2023-11-01)

• 主引用文献: Dhagat, U.,Endo, S.,Sumii, R.,Hara, A.,El-Kabbani, O.; Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid; J.Med.Chem., 51:4844-4848, 2008; PubMed: 18620380; DOI: 10.1021/jm8003575

実験手法

X-RAY DIFFRACTION (1.8 Å)