3C2K

DNA POLYMERASE BETA with a gapped DNA substrate and DUMPNPP with Manganese in the active site

3C2K の概要

• エントリーDOI: 10.2210/pdb3c2k/pdb
• 関連するPDBエントリー: 2FMS 3C2L 3C2M
• 分子名称: DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DTP*DGP*DCP*DGP*DC)-3'), DNA (5'-D(P*DGP*DTP*DCP*DGP*DG)-3'), ... (9 entities in total)
• 機能のキーワード: nucleotidyl transferase, dna polymerase, misincorporation, manganese, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, lyase, magnesium, metal-binding, nucleotidyltransferase, nucleus, polymorphism, sodium, transferase-dna complex, transferase/dna
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P06746
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48621.51

構造登録者

Batra, V.K.,Beard, W.A.,Shock, D.D.,Pedersen, L.C.,Wilson, S.H. (登録日: 2008-01-25, 公開日: 2008-05-20, 最終更新日: 2023-08-30)

• 主引用文献: Batra, V.K.,Beard, W.A.,Shock, D.D.,Pedersen, L.C.,Wilson, S.H.; Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.; Mol.Cell, 30:315-324, 2008; PubMed: 18471977; DOI: 10.1016/j.molcel.2008.02.025

実験手法

X-RAY DIFFRACTION (2.4 Å)