3BZ7

Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II

3BZ7 の概要

• エントリーDOI: 10.2210/pdb3bz7/pdb
• 関連するPDBエントリー: 1YV3 3BZ8 3BZ9
• 分子名称: Myosin-2 heavy chain, non muscle, MAGNESIUM ION, VANADATE ION, ... (6 entities in total)
• 機能のキーワード: myosin inhibitor, motor domain, blebbistatin analogue, actin-binding, atp-binding, calmodulin-binding, coiled coil, cytoplasm, methylation, motor protein, nucleotide-binding, phosphoprotein, contractile protein
• 由来する生物種: Dictyostelium discoideum
• 細胞内の位置: Cytoplasm, cell cortex: P08799
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 87630.19

構造登録者

Allingham, J.S.,Rayment, I. (登録日: 2008-01-17, 公開日: 2008-02-19, 最終更新日: 2023-08-30)

• 主引用文献: Lucas-Lopez, C.,Allingham, J.S.,Lebl, T.,Lawson, C.P.,Brenk, R.,Sellers, J.R.,Rayment, I.,Westwood, N.J.; The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.; Org.Biomol.Chem., 6:2076-2084, 2008; PubMed: 18528569; DOI: 10.1039/b801223g

実験手法

X-RAY DIFFRACTION (2 Å)