3BYM
X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck
Summary for 3BYM
Entry DOI | 10.2210/pdb3bym/pdb |
Related | 3BYO |
Descriptor | Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, N-phenyl-1-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}-1H-benzimidazol-2-amine, ... (4 entities in total) |
Functional Keywords | lck, kinase domain, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P06239 |
Total number of polymer chains | 1 |
Total formula weight | 32215.61 |
Authors | Huang, X. (deposition date: 2008-01-16, release date: 2008-09-16, Last modification date: 2023-11-15) |
Primary citation | Martin, M.W.,Newcomb, J.,Nunes, J.J.,Boucher, C.,Chai, L.,Epstein, L.F.,Faust, T.,Flores, S.,Gallant, P.,Gore, A.,Gu, Y.,Hsieh, F.,Huang, X.,Kim, J.L.,Middleton, S.,Morgenstern, K.,Oliveira-dos-Santos, A.,Patel, V.F.,Powers, D.,Rose, P.,Tudor, Y.,Turci, S.M.,Welcher, A.A.,Zack, D.,Zhao, H.,Zhu, L.,Zhu, X.,Ghiron, C.,Ermann, M.,Johnston, D.,Saluste, C.G. Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J.Med.Chem., 51:1637-1648, 2008 Cited by PubMed: 18278858DOI: 10.1021/jm701095m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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