3BXQ
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
Summary for 3BXQ
Entry DOI | 10.2210/pdb3bxq/pdb |
Related | 4INS |
Descriptor | insulin A chain, insulin B chain, ZINC ION, ... (4 entities in total) |
Functional Keywords | tr transition, electrostatic block, protein allostery, receptor binding, hormone |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 4 |
Total formula weight | 11804.21 |
Authors | Wan, Z.L.,Huang, K.,Hu, S.Q.,Whittaker, J.,Weiss, M.A. (deposition date: 2008-01-14, release date: 2008-05-20, Last modification date: 2023-08-30) |
Primary citation | Wan, Z.L.,Huang, K.,Hu, S.Q.,Whittaker, J.,Weiss, M.A. The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283:21198-21210, 2008 Cited by PubMed: 18492668DOI: 10.1074/jbc.M800235200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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