3BX7

Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4

3BX7 の概要

• エントリーDOI: 10.2210/pdb3bx7/pdb
• 関連するPDBエントリー: 3BX8
• 分子名称: CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2 (3 entities in total)
• 機能のキーワード: protein design, protein-protein complex, glycoprotein, immunoglobulin domain, polymorphism, transmembrane protein, de novo protein, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P16410
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33502.81

構造登録者

Schonfeld, D.L.,Chatwell, L.,Skerra, A. (登録日: 2008-01-11, 公開日: 2009-01-20, 最終更新日: 2023-08-30)

• 主引用文献: Schonfeld, D.L.,Matschiner, G.,Chatwell, L.,Trentmann, S.,Schlehuber, S.,Hohlbaum, A.,Skerra, A.; High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin; To be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)