3BWM

Crystal Structure of Human Catechol O-Methyltransferase with bound SAM and DNC

3BWM の概要

• エントリーDOI: 10.2210/pdb3bwm/pdb
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: comt, rossmann fold, sam, dnc, alternative initiation, catecholamine metabolism, cytoplasm, magnesium, membrane, methyltransferase, neurotransmitter degradation, polymorphism, s-adenosyl-l-methionine, transferase, transmembrane
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side: P21964
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24510.34

構造登録者

Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W. (登録日: 2008-01-09, 公開日: 2008-06-03, 最終更新日: 2023-08-30)

• 主引用文献: Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W.; Crystal structures of human 108V and 108M catechol O-methyltransferase.; J.Mol.Biol., 380:120-130, 2008; PubMed: 18486144; DOI: 10.1016/j.jmb.2008.04.040

実験手法

X-RAY DIFFRACTION (1.98 Å)