3BWI

Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with an acetate ion bound at the active site

Summary for 3BWI

Entry DOI	10.2210/pdb3bwi/pdb
Descriptor	Botulinum neurotoxin A light chain, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	botulinum neurotoxin type a, catalytic domain, endopeptidase, bio-warfare agent, hydrolase, metalloprotease, pharmaceutical, protease, secreted, zinc
Biological source	Clostridium botulinum
Cellular location	Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
Total number of polymer chains	1
Total formula weight	49974.57
Authors	Kumaran, D.,Rawat, R.,Swaminathan, S. (deposition date: 2008-01-09, release date: 2008-04-22, Last modification date: 2023-08-30)
Primary citation	Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem., 283:18883-18891, 2008 Cited by PubMed: 18434312 DOI: 10.1074/jbc.M801240200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation